BioDLS0 pages

BioDLS Microplate Particle Sizer High-throughput characterization Proteins, peptides, and other particles Aggregation or formulation studies Particle sizing by dynamic light scattering, is an invaluable technique for formulation characterization and aggregation studies. It works with unmodified, undiluted samples. It offers exquisite sensitivity to enable detection of even the initiation of aggregation, information that is invaluable to the pharmaceutical scientist concerned about loss of activity or immunogenicity in pharmaceutical prepaͭrations, or to be the pharmacologist screening for potentially therapeutic inhibitors of aggregation. Until recently, however, the power of this technology has not been capable of meeting industrial throughput requirements. Now, Brookhaven Instruments, the compaͭny that has pioneered fundamental innovation in light scattering for thirty years, is proud to an-nounce the release of the BioDLS, an instrument that combines the power of dynamic light scattering with modern automatic liquid handling to yield un-surpassed convenience and accuracy in formulation characterization and aggregation assays. The BioDLS allows automatic particle sizͭing using industry-standard well plates. The precision controlled sample transfer mechanism allows the user to select any arbitrary well to initiate the experiment, transferring as little as 2 sample volume is required for a measurement, and allows recovery of the transferred sample. Samples can be stored in up to two 384-well plates in an inde-pendently temperature-controlled compartment, and up to 768 samples can be transferred automat-ically to the flow cell without user intervention. The measuring cell has independent temperature con-trol, allowing thermal studies related to stability and aggregation on individual samples. These features, coupled with the high-throughput fluid handling, allow the sensitivity, precision, and accuracy re-quired for biotechnology and pharmaceutical reͭsearch on proteins, peptides, viruses, and antibod-ies. Nanoparticle in flow cell