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Biopharm PES Capsules0 pages
BPS Capsule Filters
PES Membrane
Applications
Buffers and Feedstocks
WFI Water
LVPs
Solvents
Vaccines
Polyethersulfone is particularly suited for the filtration of products
that contain elements that can adsorb to the media, such as
preservatives and proteins. The lower binding characteristics
of PES make it a good choice for filtration of valuable protein
solutions such as vaccines and other biologicals.
Excellent flow rates with high throughput
D
esigned for minimal leachables and extractables
Low adsorption of proteins and preservatives
Flow Rate / Filtration Area
The following table represents typical water flow at a one psi (69
mbar) pressure differential across a single 2 inch capsule with 1.0
ft² (930 cm²) of media with 1/2” FNPT ports. The test fluid is water
at ambient temperature. Higher pressure drops are acceptable,
but as flows increase the pressure drop of the housing becomes
more apparent.
Pore
Size
0.03
μm
0.10
μm
0.22
μm
0.45
μm
0.65
μm
0.8
μm
1.0
μm
1.2
μm
GPM
0.16
0.26
0.46
0.71
0.86
0.91
0.97
1.0
LPM
0.61
0.98
1.74
2.69
3.26
3.44
3.67
3.78
* For approximate flow rates for 5” through 30” capsules, refer to the
appropriate cartridge data sheet
BPS Capsule Filters - Filtration Area
Media
PES
Membrane
Capsule Length
2”
5”
10”
20”
30”
1.0 ft2
(0.93m2)
3.0 ft2
(2.78m2)
7.0 ft2
(6.50m2)
14.0 ft2
(13.01m2)
21.0 ft2
(19.51m2)
Sanitization/Sterilization
Autoclave........................... 250° F (121° C), 30 min, multiple cycles
Chemical Sanitization.......... Industry standard concentrations
of hydrogen peroxide, paracetic acid, sodium hypochlorite and
other selected chemicals.
Note................................BPS capsules are not to be used in steam.
Pre-Sterilized.............BPS capsules are offered in both non- and
pre-sterilized forms.
Maximum Operating Parameters
Housing
Polypropylene
Liquid Operational Pressure
80 psi (5.5 bar) at 20 °C (68 °F)
Filtration Media
Polyethersulfone
(PES) Membrane
Gases Operational Pressure
60 psi (4.1 bar) at 20 °C (68 °F)
Operating Temperature
Media Support
Polypropylene
43 °C (110 °F) at 30 psi
(2.1 bar) in water
End Caps
Polypropylene
Forward Differential Pressure 50 psid (3.4 bard) at 20 °C (68 °F)
Center Core
Polypropylene
Reverse Differential Pressure
40 psid (2.7 bard) at 20 °C (68 °F)
Outer Support Cage
Polypropylene
Sealing Method
Thermal Bonding
Recommended Changeout
Pressure
35 psid (2.4 bard)
Biopharmaceutical Grade
Biopharmaceutical grade PS capsules are hydrophilic
and manufactured with the highest quality asymmetric
polyethersulfone (PES) membrane. PES membrane exhibits
excellent flow rates with high throughput. BPS capsule filters
are used for bioburden reduction applications in the biologicals
industry. Specific applications for BPS capsule filters are bacteria
removal in buffers, USP Water for Injection (WFI), SVPs, LVPs and
other biological products. The filter elements are 100% integrity
tested during production.
Validated for use in multiple biopharmaceutical
applications
Construction Materials
SVPs
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