Pharma Positively Charged Nylon 6,6 Cartridge Filters0 pages

PNC Cartridge Filters
Positively Charged Nylon 6,6 Membrane

Diagnostics

Dialysis Applications

LVPs and SVPs

Biologicals

Water for Injection

Endotoxin Reduction

Integrity Test Specifications
Per 10-in. length, water-wetted membrane
Pore Size
0.10 μm

Filtration Media

Positively Charged Nylon 6,6
Membrane

Media Support

Polypropylene

End Caps

Polypropylene

Center Core

Polypropylene

Outer Support Cage

Polypropylene

Sealing Method

Thermal Bonding

O-rings

Buna, Viton® (or FKM), EP, Silicone,
FEP Encapsulated Silicone, FEP
Encapsulated Viton (or FKM)

Note: All materials of construction are FDA accepted. Final assemblies have
been validated to pass USP Class VI toxicology extractable tests, oxidizable
substances for plastics, endotoxin level, and other quality tests.

Dimensions
Length

5 to 40 in. (12.7 to 101.6 cm) nominal

Outside Diameter

2.75 in. (7.0 cm) nominal

Filtration Area

7.0 ft2 (0.65 m2) per 10 in. length

< 15 cc/min at 35 psig (2.4 barg)

0.45 μm

Construction Materials

< 15 cc/min at 48 psig (3.3 barg)

0.22 μm

PNC Membrane Filter Cartridges are sterilizing grade cartridges
with charged Nylon 6,6 membrane. The nylon membrane used in
these cartridges is positively charged for enhanced retention of
particles below the rated pore size of the filter. Nylon cartridges see
broad service in sterile fill applications in SVPs and as bioburden
management filters in LVPs. Media preparation and service liquid
filtration are other common applications for this cartridge. Positively
charged nylon is particularly suited for endotoxin removal in water
systems. Nylon is also used for filtration of solvents because of its
broad compatibility and low level of extractables.

Air Diffusion Rate

< 15 cc/min at 20 psig (1.4 barg)

0.65 μm

< 15 cc/min at 15 psig (1.0 barg)

Maximum Operating Parameters
Differential Pressure
•t Forward

50 psid (3.4 bard) at 20 °C (68 °F)

•t Reverse

40 psid (2.7 bard) at 20 °C (68 °F)

Operating Temperature
Recommended
Changeout Pressure

82 °C (180 °F) at 10 psid
(0.69 bard) in water
35 psid (2.4 bard)

Sanitization/Sterilization
Filtered Hot Water

90 °C (194 °F), 30 minutes, multiple
cycles, max 3 psid forward flow

Autoclave

121 °C (250 °F), 30 min, multiple cycles

In-line Steam

135 °C (275 °F), 30 min, multiple cycles

For all elevated temperature procedures above, a stainless steel
support ring is required.
Chemical Sanitization
Nylon does not tolerate aggressive chemical sanitization
protocols. Nylon membrane cartridges are best sanitized with
1% hydrogen peroxide or 1% hydrogen peroxide and peracetic
acid. Various manufacturers use different concentrations of
active ingredients. Refer and adhere to the manufacturer’s
instructions for sanitizing nylon membrane.

Endotoxin Removal

PNC filters removed up to 99.9% of endotoxin when challenged
with between 3EU/ml and 240EU/ml.

Pharmaceutical Grade

Applications